What are the causes of RT3
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The body naturally produces some RT3 and this isn't a problem in most people. The problem arises when the ratio of FT3 to RT3 sinks too low as the RT3 then gets in the way of the T3 that we need to function causing hypothyroid symptoms.

There are several causes for this ratio getting disturbed, the principal ones that we know of are:-

• Extreme dieting, the RT3 increases to slow the metabolism and make better use of the available food
• Low Iron (including Ferritin)
• High cortisol, this disturbs the balance of the thyroid hormones
• Low cortisol, this again disturbs the balance of the thyroid hormones
• Insulin dependent Diabetes
• Low Vitamin B12 levels
• Graves disease or other causes of being Hyper Thyroid  (New 10/10)
• Other forms of thyroid resistance causing heavy supplementation of thyroid Meds (new 10/10).

In addition to these common causes there are a large list of causes which I have copied from here

Ageing [12]
Burns/thermal injury[63]
Caloric restriction and fasting[64-66]
Chemical exposure[67]
Cold exposure[68]
Chronic alcohol intake[69]
Free radical load[30]
Hemorrhagic shock[70]
Insulin-dependent diabetes mellitus[71]
Liver disease[31]
Kidney disease[72,73]
Severe or systemic illness[74]
Severe injury[76]
Stress[77]
Surgery[15,78-80]
Toxic metal exposure[26-29]

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